اینٹی بائیوٹک مزاحمت خاص طور پر گرام منفی بیکٹیریا نے تقریباً ایک بحران جیسی صورتحال پیدا کر دی ہے۔ ناول اینٹی بائیوٹک Zosurabalpin (RG6006) وعدوں کو ظاہر کرتا ہے۔ پری کلینیکل اسٹڈیز میں یہ منشیات کے خلاف مزاحم، گرام منفی بیکٹیریا CRAB کے خلاف موثر پایا گیا ہے۔
Antimicrobial resistance (AMR), driven mainly by the misuse and overuse of antimicrobials, is one of top public health risk.
Infections by Gram-negative bacteria are particularly concerning. It is not easy for most of اینٹی بایوٹک to cross both inner and outer membranes present in this category of bacteria to enter the bacterial cells to show bactericidal actions. Also, Gram-negative bacteria have accumulated disproportionately high degree of اینٹی بائیوٹک مزاحمت
ایکنٹوبیکٹر بومنی is a Gram-negative bacterium. Infection by one of its strains called ‘carbapenem-resistant Acinetobacter baumannii’ (CRAB) is hard to treat using available اینٹی بایوٹک. There is an urgent need for an effective اینٹی بائیوٹک against CARB as mortality rate is high (about 40%-60%) which attributed largely to lack of an effective اینٹی بائیوٹک. A progress towards this goal has been reported.
Scientists have identified a novel class of اینٹی بایوٹک namely, tethered macrocyclic peptides (MCPs) which are active against the Gram –ve bacteria A. baumannii including CARB by blocking transport of bacterial lipopolysaccharide from the inner membrane to the outer membrane.
Zosurabalpin (RG6006) ہے ایک اینٹی بائیوٹک candidate belonging to ‘tethered macrocyclic peptides (MCPs)’ class. In pre-طبی trials involving in vitro studies and in vivo studies on animal models, Zosurabalpin has been found to be effective against drug-resistant isolates of ‘carbapenem-resistant Acinetobacter baumannii’ (CRAB) from different regions. It successfully overcame اینٹی بائیوٹک-resistance mechanism of CARB suggesting زوسوربالپین صلاحیت ہے.
Hence, human طبی trials have been initiated to check for safety and efficacy زوسوربالپین CRAB کی وجہ سے ناگوار انفیکشن کے علاج میں۔
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حوالہ جات:
- Zampaloni, C., Mattei, P., Bleicher, K. et al. A novel اینٹی بائیوٹک class targeting the lipopolysaccharide transporter. Nature (2024). https://doi.org/10.1038/s41586-023-06873-0
- ہاوزر ایس، ET اللہ تعالی 2023. Activity of the Novel Antibiotic Zosurabalpin (RG6006) against کلینکل Acinetobacter Isolates from China, Open Forum Infectious Diseases, Volume 10, Issue Supplement_2, December 2023, ofad500.1754, https://doi.org/10.1093/ofid/ofad500.1754
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